2/14/2023 0 Comments Sandra orlow nudeConclusions: Our data demonstrate that vemurafenib induces ER stress response–mediated autophagy in thyroid cancer and autophagy inhibition may be a beneficial strategy to sensitize BRAF-mutant thyroid cancer to vemurafenib. Wang, Weibin Kang, Helen Zhao, Yinu Min, Irene Wyrwas, Brian Moore, Maureen Teng, Lisong Zarnegar, Rasa Jiang, Xuejun Fahey, Thomas J Targeting Autophagy Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib. The RAF inhibitor vemurafenib has provided a major advance for the treatment of patients with BRAF-mutant metastatic melanoma. However, BRAF-mutant thyroid cancer is relatively resistant to vemurafenib, and the reason for this disparity remains unclear. Anticancer therapy-induced autophagy can trigger adaptive drug resistance in a variety of cancer types and treatments.
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